Overview
Chronic glomerulonephritis as chronic nephritis, to proteinuria, hematuria, high blood pressure, edema as the basic clinical features, different ways onset, protracted illness, the slow progress of disease, can have different degrees of renal dysfunction, will eventually The development of chronic renal failure for a group of glomerular disease. As the group of diseases and disease pathology types of different, the main clinical manifestations can be different, the performance of the disease becoming diversified.
Etiology and pathogenesis
Only a small number of chronic nephritis is due to the development of acute nephritis Community. But most of unclear etiology, and pathogenesis of acute nephritis similar to their own immune response is a process. But why the process leading to chronic mechanism is not clear, there may be some of the body immune function related defects. The body immune function flaw allows a reduced ability to fight infections, repeatedly incurred microbial invasion; body can not produce enough of the antibody to remove pathogenic substance , resulting in continued retention of antigen to the body and form immune complexes, deposited in Kidney, a chronic inflammatory process.
In addition, non-immune-mediated kidney damage in the incidence of chronic nephritis and development also may play an important role, such as renal unit-of compensatory increased serum perfusion pressure, glomerular filtration loop transmembrane pressure and pressure Increase may lead to glomerulosclerosis. In the course of the disease hypertension, exist for a long time, can lead to renal artery stenosis, occlusion and accelerate glomerulosclerosis.
Pathological
Chronic nephritis is the pathological changes of the two diffuse glomerular kidney disease. Because chronic inflammation process, glomerular gradually destroyed, fibrous hyperplasia; glomerular fibrosis, glass-like change, a non-glass-like structure of the corporation. As glomerular blocked blood flow, the corresponding tubular atrophy and fibrosis, interstitial fiber proliferation, lymphocyte infiltration. Kidney disease less flat in compensatory mast in the glomerular sclerosis sometimes visible between the glomerular hypertrophy, generally have the following types: ① mesangial proliferative glomerulonephritis; ② membrane proliferation nephritis; ③ focal proliferative glomerulonephritis; ④ membranous nephropathy; ⑤ or focal segmental glomerulosclerosis. As the progressive development of lesions, leading to serious kidney damage, formation of end-stage renal shrinkage.
