Under the general pathological examination kidney involvement, accounting for about 90 percent, from the pathogenesis of view, susceptible to genetic factors is only a tendency, environmental factors trigger the disease in this play an important role in, such as virus infection, drugs, and sunlight radiation, and so on. The disease found in more than 90 percent of women, a Green, a middle-aged women with kidney disease performance, with multi-system disease, in particular, fever, arthritis, skin rash, erythrocyte sedimentation rate was significantly higher, should be suspected of the disease and should be doing routine And check the disease of the immune serum testing to the diagnosis. Pathological changes and the prognosis is most closely connected, and kidney involvement and progressive renal dysfunction of this disease is one of the major causes of death, the lupus nephritis patients do puncture kidney biopsy is very important in determining treatment and prognosis very meaningful .
According to the U.S. Institute of Rheumatology in 1997 recommended systemic lupus erythematosus diagnostic criteria:
1. Erythema flat or high-cheek, the zygomatic prominent positions in the two fixed erythema.
2. Discoid superb red flake of skin erythema, scaling and adhesion are horny hair follicles suppository; old lesions can occur atrophic scars.
3. - Allergy to sunlight is obvious reaction, cause skin rash, from the history of that or doctors observed.
4. Oral ulcers by doctors to observe the nasopharynx or oral ulcers, is generally painless.
5. Arthritis erosion of the non-arthritis, involving two or more of the peripheral joints, tenderness, swelling or fluid.
6. Serositis of pleurisy or pericarditis.
7. Kidney disease urine protein 0.5g/24h or + + +, or tube-type .
8. Neuropathy epilepsy or mental illness, drug or known except for the metabolic disorder.
9. Blood disease hemolytic anemia or neutropenia, or lymphocytes reduce, or thrombocytopenia.
10. Immunological abnormalities anti-dsDNA antibody, or anti-Sm-positive, or antiphospholipid antibody positive .
11. Anti-nuclear antibody at any time and did not use drug-induced drug-induced lupus, anti-nuclear antibody anomaly.
The diagnostic criteria of 11, with four or four or more, except in the infection, cancer and other connective tissue disease, the diagnosis can be systemic lupus erythematosus, along with article 7 of kidney disease can be diagnosed as lupus Nephritis.
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