Filamentous keratopathy mainly for the epithelial cells were attached to one end of filamentous vol corneal surface and with the attachment point next to a row of corneal epithelial cells, and the other end of a free state, with a clear sense of foreign body, accompanied photophobia flow Tears symptoms. About filamentous corneal diseases cause, is not a single cause can explain, the traditional view that may be related to the following factors: ① epithelial cell proliferation, ② basement membrane with a stretch of the joint abnormalities, ③ tear mucus formation of excessive , ④ corneal wound healing process of epithelial cells lost contact inhibition, ⑤ packet eyes of the eye caused the temperature rise]. Medline record of 10 years of filamentous keratopathy Shi Yupian the only ophthalmic literature. We already know, the corneal epithelial growth and apoptosis keep a balance in an orderly manner, so as to maintain its integrity and smooth, the occurrence of filamentous keratopathy may have unknown corneal epithelial growth imbalance in the complex mechanism of control. Cornea after PRK next to the Central District and the Central District epithelial was curettage, the basement membrane, before the Stretch layers and layers of the matrix was cutting, and accepted the ultraviolet region of the excimer laser radiation, and contact lens coverage after Patients because of photophobia, pain and eyes closed, all of these factors are likely to interfere with corneal epithelial growth and the dynamic balance between apoptosis, resulting in corneal disease occurred in filamentous potential role can not be ruled out. Basement membrane is the corneal epithelial cells of normal attachment, migration and growth of one of the major conditions, Ljubimov and Kurpakus that basement membrane composition and configuration of its impact on the adhesion of cells, for their phenotype, differentiation and function Induction of the important role of the basement membrane of the missing will definitely affect the normal repair corneal epithelium. Of eye pain after PRK, the lacrimal gland secretion increased, the lacrimal gland cells and secretion of epithelial growth factor to tear, which means to increase production outside the corneal epithelial and stromal repair, EGF increased mainly through the restoration of corneal epithelial cell proliferation mechanism to To achieve. Baum eyes closed for the extension of the cornea is the risk factors, including the wearing soft contact lenses, long time eyes closed cause cornea in a state of hypoxia caused corneal diseases, such as filamentous Jiaomo Bing happen. Also because of cornea absorb almost 100 percent lower than the 290 nm wavelength ultraviolet light, the wavelength of 193 nm excimer laser is absorbed corneal epithelium will induce a certain degree of variation of corneal cells have yet to be research. We believe that, because the deeper the cutting surface and cutting surface is not smooth so that the corneal epithelial repair early attachment difficulties, resulting in more filamentous keratopathy in corneal laser cutting edge area, but also occurred in more than cutting deeper in the high myopia patients.
Filamentous keratopathy after PRK have the following characteristics: ① mostly in after four days, a week after a rare, ② a site keratectomy edge of the main areas, and the limbal cornea and the Department of the Central 1 ~ 2 mm in diameter within the region more Shao, ③ -3.00 D following refractive errors are rare, with the increase in refraction, the incidence has increased, ④ the good men than women, ⑤ eyesight after regression and haze in a special situation. Patients of all ages have occurred. From the onset and follow-up situation, PRK after filamentous keratopathy is a transient corneal epithelial growth of the state went out of control, but the exact pathogenesis, the incidence of the reasons for the gender differences in age and the incidence of the relations and other issues remain to be In-depth study.
